Affiliations: Medical Faculty Hospital, Clinic of Geographic
Medicine, Prague, Czech Republic | Department of Clinical Epidemiology, Aalborg Hospital
and Aarhus University Hospital, and Department of Epidemiology and Social
Medicine, Aarhus University, Denmark | The Heart Centre, Department of Medicine B, Copenhagen
University Hospital, Denmark | Pharma Nord ApS, Sadelmagervej 30-32, 7100 Vejle,
Denmark
Note: [] Address for correspondence: Douglas A. Hunter, Pharma Nord
Research, Sadelmagervej 30-32, 7100 Vejle, Denmark. Tel.: +45 75 85 74 00; Fax:
+45 75 85 85 40; E-mail: dhunter@pharmanord.com
Abstract: Serum coenzyme Q_{10} (Q_{10})
concentrations were evaluated in healthy male volunteers supplemented with
30 mg or 100 mg Q_{10} or placebo as a single daily dose for
two months in a randomised, double-blind, placebo-controlled study. Median
baseline serum Q_{10}concentration in 99 men was 1.26 mg/l
(10%, 90% fractiles: 0.82, 1.83). Baseline serum Q_{10}
concentration did not depend on age, while borderline significant positive
associations were found for body weight and smoking 1–10 cigarettes/d.
Supplementation with 30 mg or 100 mg Q_{10} resulted in
median increases in serum Q_{10} concentration of 0.55 mg/l
and 1.36 mg/l, respectively, compared with a median decrease of 0.23 mg/l with
placebo. The changes in the Q_{10} groups were significantly
different from that in the placebo group, and the increase in the 100 mg
Q_{10} group was significantly greater than that in the
30~mg Q_{10} group. The change in serum
Q_{10}concentration in the Q_{10} groups
did not depend on baseline serum _{10} concentration, age,
or body weight.
