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Issue title: The Third Conference of the International CoQ10 Association
Article type: Research Article
Authors: Sinatra, Drew S. | Sinatra, Stephen T. | Heyser, Charles J.
Affiliations: Department of Psychology, Franklin & Marshall College, Lancaster, PA, USA | University of Connecticut School of Medicine, Farmington, CT, USA
Note: [] Address for correspondence: Stephen T. Sinatra, M.D., F.A.C.C., 257 East Center Street, Manchester, CT 06040, USA. Tel.: +1 860 643 5101; Fax: +1 860 533 9747; E-mail: nehcpiazza@aol.com
Abstract: To explore the possibility that Coenzyme Q_{10} (CoQ_{10}) supplementation stabilizes psychomotor behavioral function in the aging organism, the behavioral effects of CoQ_{10} were evaluated in young adult male C57BL/6 mice (3 months of age) and aged C57BL/6 mice (24 months of age). Mice treated with CoQ_{10} exhibited significantly greater locomotor activity as reflected by an increase in square crosses than non-drug controls. The administration of CoQ_{10} increased all aspects of exploratory behavior in the open field. The effect was uniform across all mice and did not interact with age. Younger animals and aged animals treated with CoQ_{10} may adapt rapidly to novel areas, or they are less fearful of exploration. The behavioral activation observed in CoQ_{10} treated mice may be the result of increased locomotor activity, psychomotor stimulation, or decreased anxiety.
Keywords: mice, CoEnzyme Q[TeX:] _{10}, psychomotor stimulation, exploratory behavior, anxiety
Journal: BioFactors, vol. 18, no. 1-4, pp. 283-287, 2003
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