Affiliations: Laboratory of Renal Lithiasis Research, Faculty of
Science, University of Illes Balears, 07071 Palma de Mallorca, Spain | Department of Medical and Research Technology,
University of Maryland School of Medicine, Baltimore, MD 21201, USA | Department of Pathology, University of Maryland School
of Medicine, Baltimore, MD 21201, USA
Note: [] Laboratory of Renal Lithiasis Research, Faculty of Sciences,
University of Illes Balears, Ctra. Valldemossa Km 7,5, 07071 Palma de Mallorca,
Spain. Tel.: +31 971 17 32 57; Fax: +31 971 17 34 26; E-mail: dqufgf0@ps.uib.es
Abstract: A study of the pharmacokinetic profile (oral absorption and renal
excretion) of inositol hexaphosphate or phytate (IP_6) is
presented. Seven healthy volunteers were following a IP_6
poor diet (IP_6PD) in a first period, and on
IP_6 normal diet (IP_6ND) in a second
one. When following the IP_6PD they become deficient in
IP_6, the basal levels found in plasma (0.07±
0.01 mg/L) being clearly lower than those found when
IP_6ND was consumed (0.26± 0.03 mg/L).
During the restriction period the maximum concentration in plasma were obtained
4 h after the ingestion of a single dose of IP_6, observing
almost the same renal excretion profiles for the three different comercial
sources and doses. After the IP_6 restriction period,
volunteers were on IP_6ND, reaching normal plasma and
urinary IP_6 values in 16 days. Thus, the normal plasma and
urinary concentrations, can be obtained either by comsumption of a
IP_6ND taking a long time or in a short period by
IP_6 supplements.
Journal: BioFactors, vol. 15, no. 1, pp. 53-61, 2001
