Chemopreventive effects of coffee bean and rice constituents on colorectal carcinogenesis

Article type: Research Article

Authors: Hideki Mori, | Kunihiro Kawabata, | Kengo Matsunaga, | Jun Ushida, | Keiko Fujii, | Akira Hara, | Takuji Tanaka, | Hiromichi Murai,

Affiliations: Department of Pathology, Gifu University School of Medicine, Gifu 500-8705, Japan | Department of Pathology, Kanazawa Medical University, Japan | Oryza Oil and Fat Chemical Co., Japan

Note: [] Department of Pathology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu 500-8705, Japan. Fax: +81 58 265 9005

Abstract: Polyphenolic compound chlorogenic acid (CGA) known to be much contained in coffee beans was found to have a regressive effect on induced aberrant crypt foci (ACF) as well as on development of ACF in azoxymethane (AOM)-induced colorectal carcinogenesis in rats. Rice germ and \gamma-aminobutyric acid-enriched defatted rice germ inhibited AOM-induced ACF formation and colorectal carcinogenesis in rats. Ferulic acid (FA) also known to be contained in coffee beans and rice prevented AOM-induced ACF formation and intestinal carcinogenesis in rats. Both of food factors, coffee and rice may be of benefit to prevention of human colorectal cancers.

Keywords: chlorogenic acid, ferulic acid, coffee, rice, colorectal carcinogenesis

Journal: BioFactors, vol. 12, no. 1-4, pp. 101-105, 2000