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Issue title: Frontiers in Biomedical Engineering and Biotechnology – Proceedings of the 2nd International Conference on Biomedical Engineering and Biotechnology, 11–13 October 2013, Wuhan, China
Article type: Research Article
Authors: Zhang, Chi; | Wang, Ling | Li, Xiaoyun | Li, Shuyu | Pu, Fang; | Fan, Yubo; | Li, Deyu; ;
Affiliations: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, No. 37 Xueyuan Road, Haidian District, Beijing, 100191, China | State Key Lab of Virtual Reality of Technology and Systems, Beihang University, No. 37 Xueyuan Road, Haidian District, Beijing, 100191, China
Note: [] This study was supported by the National Key Technology R & D Program (2012BAI19B04), National Natural Science Foundation of China (No. 61190122) and the grant from the State Key Laboratory of Virtual Reality Technology and Systems, Beihang University.
Note: [] Corresponding author: Deyu LI, Email: deyuli@buaa.edu.cn
Abstract: Circle of Willis (CoW) plays a significant role in maintaining the blood supply for the brain. Specifically, when the stenosis occurs in the internal carotid artery (ICA), abnormal structures of CoW would decrease the compensatory capacity, leading to the local insufficiency of cerebral blood supply. The present paper built a series of lumped parameter models for CoW, and simulated the blood redistribution caused by the unilateral ICA stenosis with different severities in cerebral arteries in the normal and abnormal CoW respectively. The results showed that when unilateral ICA stenosis occurred, the collateral circulation was built through the anterior communicating artery and the ipsilateral posterior communicating artery, maintaining the flow in cerebral arteries. The absence of the two communicating arteries would cause an obvious decrease of flow in local cerebral arteries in the anterior circulation. In conclusion, the two arteries play a significant role in maintaining the balance of cerebral blood supply in the development of ICA stenosis.
Keywords: Circle of Willis, internal carotid artery, stenosis, anatomical variation, lumped parameter model
DOI: 10.3233/BME-130835
Journal: Bio-Medical Materials and Engineering, vol. 24, no. 1, pp. 491-499, 2014
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