Correlation between the characteristics of acceleration and visco elasticity of artery wall under pulsatile flow conditions (physical meaning of I* as a parameter of progressive behaviors of atherosclerosis and arteriosclerosis)
Issue title: Special Issue on Artificial Organs and Regenerative Medicine dedicated to the late Prof. Yukihiko Nosé
Affiliations: Faculty of Graduate School of Engineering, Tohoku University, Sendai, Japan | Sendai Japan Railways Hospital, Sendai, Japan | Department of Ophthalmology and Visual Science, Yamagata University Faculty of Medicine, Yamagata, Japan
Note: [] Address for correspondence: A. Toshimitsu Yokobori, Jr., Faculty of Graduate School of Engineering, Tohoku University, Sendai, Japan. E-mail: yokobori@md.mech.tohoku.ac.jp
Abstract: Previously, I* parameter has been proposed to diagnose noninvasively the progressive degree of atherosclerosis which is considered to concern the discrimination of the progressive degree of visco elasticity of blood vessel wall. However, the detailed physical meaning of this parameter has not yet been clarified. In this paper, the theoretical analysis and experiments were conducted and the detailed physical meaning of I* parameter was clarified. The following results were obtained. I* parameter was found to well correlate with the progressive degree of visco elasticity of blood vessel wall characterized by the Ith* parameter derived based on the analysis of visco elasticity in this paper. That is, I* was found to have the physical meaning of representing the progressive degree of visco elasticity of blood vessel wall. On the basis of this results, using clinical data, two dimensional representation between the progressive degree of visco elasticity of blood vessel wall by I* and the decrease in the rigidity of blood vessel wall by PWV was found to be useful to conduct much more detailed diagnosis of atherosclerosis.
