Post-translational proteolytic events influence LRP-1 functions

Issue title: Papers from the 5th Scientific Meeting on Cartilage Engineering, February 2010, Nancy, France

Article type: Research Article

Authors: Selvais, Charlotte | Dedieu, Stéphane | Hornebeck, William | Emonard, Hervé^;

Affiliations: Cell Biology Unit, de Duve Institute, Université Catholique de Louvain, Bruxelles, Belgium | Faculté de Médecine, CNRS UMR 6237, Université de Reims Champagne-Ardenne, Reims, France

Note: [] Address for correspondence: Hervé Emonard, Faculté de Médecine, CNRS UMR 6237, Université de Reims Champagne-Ardenne, 51 rue Cognacq-Jay, 51095 Reims, France. Tel.: +33 3 26 91 80 56; Fax: +33 3 26 91 80 55; E-mail: herve.emonard@univ-reims.fr.

Abstract: The low-density lipoprotein receptor-related protein (LRP-1) is a membrane receptor displaying both endocytic scavenging and signaling functions. In this review, we briefly present post-translational proteolytic processes targeting this receptor and speculate on their possible influence on LRP-1 biological functions.

Keywords: Endocytosis, low-density lipoprotein receptor-related protein, regulation, shedding, signaling

DOI: 10.3233/BME-2010-0633

Journal: Bio-Medical Materials and Engineering, vol. 20, no. 3-4, pp. 203-207, 2010