Genetic modification of mesenchymal stem cells for cartilage repair

Issue title: Papers from the 5th Scientific Meeting on Cartilage Engineering, February 2010, Nancy, France

Article type: Research Article

Authors: Cucchiarini, Magali | Madry, Henning

Affiliations: Experimental Orthopaedics and Osteoarthritis Research, Saarland University Medical Center, Homburg/Saar, Germany

Note: [] Address for correspondence: Dr. Magali Cucchiarini, PhD, Experimental Orthopaedics and Osteoarthritis Research, Saarland University Medical Center, Kirrbergerstr. Bldg 37, D-66421 Homburg/Saar, Germany. E-mail: mmcucchiarini@hotmail.com.

Abstract: Reproduction of a native, functional architecture in articular cartilage defects is a major problem in orthopaedic surgery. The elaboration of workable options to heal damaged cartilage might necessitate to involve cellular, molecular and environmental components to allow for the formation of an adequate and stable repair tissue in sites of injury. Strategies based on the transfer of candidate sequences to progenitor cells offer powerful tools to achieve this goal. The aim of this report is to provide an overview of the most recent therapeutic approaches developed in experimental orthopaedic research.

DOI: 10.3233/BME-2010-0625

Journal: Bio-Medical Materials and Engineering, vol. 20, no. 3-4, pp. 135-143, 2010