Effects of heat treatment on the bioactivity of surface-modified titanium in calcium solution
Issue title: Selected papers presented at the International Symposium on Nanotoxicity Assessment and Biomedical Environmental Application of Fine Particles and Nanotubes, Hokkaido, Japan, 16–17 June 2008, Part 2
Affiliations: Department of Oral and Maxillofacial Prosthodontics, Institute of Health Biosciences, Tokushima University Graduate School, Tokushima, Japan | Department of Biomaterials and Bioengineering, Institute of Health Biosciences, Tokushima University Graduate School, Tokushima, Japan
Note: [] Address for correspondence: Kenichi Hamada, PhD, Department of Biomaterials and Bioengineering, Institute of Health Biosciences, Tokushima University Graduate School, 3-18-15 Kuramoto, Tokushima 770-8504, Japan. Tel.: +81 88 633 7334; Fax: +81 88 633 9125; E-mail: hamada@dent.tokushima-u.ac.jp.
Abstract: The purpose of this study was to determine the effects of heat treatment on the bioactivity of hydrothermal-modified titanium in CaO solution for improved bioactivity by immersion in simulated body fluid (SBF). The hydrothermal treatment of titanium in CaO solution was performed at 121°C at 0.2 MPa for 1 h in an autoclave followed by 1 h heat treatments at 200, 400, 600 and 800°C simultaneously. The bioactivity of titanium was evaluated by hydroxyapatite precipitation during immersion in SBF. Surface microstructure changes after the heat treatments and immersion in SBF were determined by X-ray diffractometry (XRD), X-ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM). Heat treatments at high temperatures (600 and 800°C) promoted the synthesis of anatase, increased the thickness of the titanium oxide layer on the modified titanium surface and promoted the synthesis of calcium titanate, which possibly promoted the precipitation of apatite in SBF. The extent of precipitations increased with the time of immersion in SBF and the temperature of the heat treatment. Island-like deposits of needle-like crystals were observed only on the surface of the 600 and 800°C heat-treated specimens after two or four week immersions in SBF. The results suggested that treatments of the surface of hydrothermal-treated titanium specimens at high temperatures (600 and 800°C) could be effective for the surface modification of titanium as an implant material offering better osseointegration.
