Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Khang, Gilson | Jeong, Bong Jin | Lee, Hai Bang | Park, Joon B.;
Affiliations: Department of Biomedical Engineering, College of Engineering, The University of Iowa, Iowa City, IA 52242, USA | Biomaterials Laboratory, Korea Research Institutes of Chemical Technology, P.O. Box 107, Yusung, Taejon, 305-606, Korea
Note: [] Author to whom correspondence should be addressed.
Abstract: Expelimental results on the platelet adhesion, and CHO cell adhesion and growth onto nonionic surfactant which is composed of a long alkyl chain (n = 12~18) as the hydrophobic part, and a polyethyleneoxide (PEO) segment (n = 10~23) as the hydrophilic part coated and air-plasma treated PSf surfaces are presented in terms of PEOs functionality and surface wettability to improved blood- and cell-compatibility of polysulfone. Platelet adhesion experiments on surface treated PSf films were carried out with platelet enriched plasma (PRP) in the parallel flow chamber in vitro. Number and morphology of adhered platelets were observed by scanning electron microscope. The number of adhered platelets on non ionic surfactant coated surfaces decreased significantly compared to the control. Also, the adhesion of platelets on to PSf substrate decreased with increasing coating concentration of nonionic surfactant. In the dry air-plasma exposed PSf sample, the adhesion of platelets decreased independently of plasma exposure time, and significant diminution of platelet adhesion was observed below about 40° of the contact angle. It is believed that less platelet adhesion is preceded by less protein adsorption due to hydrophobic dehydration interaction. In Chinese hamster ovary (CHO) cell, adhesion and growth cells grew better on the air-plasma treated PSf surfaces. From these results, it can be proposed that surface wettability of PSf is very important for cell adhesion and growth.
Keywords: polysulfone, nonionic surfactant, air-plasma treatment, platelet adhesion, Chinese hamster ovary (CHO), cell, cell attachment and growth, polyethylene oxide functionality, surface wettability
DOI: 10.3233/BME-1995-5406
Journal: Bio-Medical Materials and Engineering, vol. 5, no. 4, pp. 259-273, 1995
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
sales@iospress.com
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
info@iospress.nl
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office info@iospress.nl
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
china@iospress.cn
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
如果您在出版方面需要帮助或有任何建, 件至: editorial@iospress.nl