Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Yokobori, Jr., A. Toshimitsu | Miyasaka, Yoshinori | Sakurai, Minoru
Affiliations: Faculty of Engineering, Tohoku University, Aoba Aramaki, Aobaku, Sendai 980-77, Japan | Department of Orthopaedic Surgery, Tohoku University, Aobaku Seiryochou 1-1, Sendai 980-77, Japan
Abstract: Osteogenesis is completed by the nucleation mechanism on crystal nuclei formation and growth after amorphous calcium phostate accretion to collagen fibers. For nuclei formation, it is necessary to have preliminary ionic diffusion such as that of Ca2+ and PO43− ions to this part. Therefore, promotion of ionic diffusion to this part is the first essential condition for osteogenesis. We have considered this phenomenon as the nucleation mechanism accompanied by preliminary diffusion behavior and shown the optimum mechanical condition on promoting this ionic diffusion. Furthermore, we noticed callus by callotasis as the typical example which fits this mechanical condition and investigated its histology. However, necking occurs at the site of callus sandwiched by cortical bones due to tensile stress, three axial tensile stress in radial and tangential directions, in addition to the tensile stress occurs at the netsection of the callus due to the constraint of cortical bones. Therefore, the size of pore along the collagen lamination and hole zone becomes large under this mechanical condition and ionic diffusion such as Ca2+, PO43− is liable to occur at this part. By solving the partial differential equation of the stress-induced diffusion, diffusive particles are shown to concentrate at the high three axial tensile stress region. Therefore, a high concentrated region of Ca, PO4 is achieved and selective osteogenesis due to hydroxyapatite nucleation is considered to progress in this region. Histological investigation of the callus of rabbit showed that mineralization occurs at this site and supports the theory of stress-induced diffusion on osteogenesis behavior.
Keywords: osteogenesis, mineralization, calcium diffusion, tensile stress, callus
DOI: 10.3233/BME-1995-5402
Journal: Bio-Medical Materials and Engineering, vol. 5, no. 4, pp. 209-217, 1995
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
sales@iospress.com
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
info@iospress.nl
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office info@iospress.nl
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
china@iospress.cn
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
如果您在出版方面需要帮助或有任何建, 件至: editorial@iospress.nl