Cartilage and bone tissue engineering using hydrogels

Issue title: Cell and Tissue Bioengineering and Therapy, Nancy 2005, 10–11 May

Article type: Research Article

Authors: Vinatier, C.^; | Guicheux, J.^{; ;} | Daculsi, G.^; | Layrolle, P.^; | Weiss, P.^;

Affiliations: Inserm 791, Nantes, France | University of Nantes, Faculté de chirurgie dentaire, 1 place Alexis Ricordeau, F-44042 Nantes cedex, France

Note: [] Corresponding author. Fax: +33 2 40 08 37 12; E-mail: jerome.guicheux@nantes.inserm.fr.

Abstract: Tissue engineering is an emerging field of regenerative medicine which holds promise for the restoration of tissues and organs affected by chronic diseases, age-linked degeneration, congenital deformity and trauma. During the past decade, tissue engineering has evolved from the use of naked biomaterials, which may just replace small area of damaged tissue, to the use of controlled three-dimensional scaffolds in which cells can be seeded before implantation. These cellularized constructs aims at being functionally equal to the unaffected tissue and could make possible the regeneration of large tissue defects. Among the recently developed scaffolds for tissue engineering, polymeric hydrogels have proven satisfactory in cartilage and bone repair. Major technological progress and advances in basic knowledge (physiology and developmental biology) are today necessary to bring this proof of concept to clinical reality. The present review focuses on the recent advances in hydrogel-based tissue engineered constructs potentially utilizable in bone and cartilage regenerative medicine.

Journal: Bio-Medical Materials and Engineering, vol. 16, no. 4, pp. S107-S113, 2006