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Article type: Research Article
Authors: Ozeki, K.; | Okuyama, Y. | Fukui, Y. | Aoki, H.
Affiliations: Frontier Research and Development Center, Tokyo Denki University, Ishizaka, Hatoyama, Hiki, Saitama 350-0394, Japan | Graduate School of the 1st Oral and Maxillofacial Surgery, The Nippon Dental University, Japan | Applied Systems Engineering, Graduate School of Science and Engineering, Tokyo Denki University, Ishizaka, Hatoyama, Hiki, Saitama 350-0394, Japan
Note: [] Corresponding author: K. Ozeki, Frontier Research and Development Center, Tokyo Denki University, Ishizaka, Hatoyama, Hiki, Saitama 350-0394, Japan. Tel.: +81 49 296 2911 (3761), Fax: +81 49 296 2925; E-mail: ozeki@frontier.f.dendai.ac.jp.
Abstract: Hydroxyapatite (HA) was coated onto titanium implants using radio frequency magnetron sputtering. The HA films were crystallized in an autoclave tube using low temperature hydrothermal treatment. The average film thickness on the implant was 1.1 μm. HA-coated and pure-titanium implants were inserted into canine mandibles for up to 24 weeks. Forty-eight implants were placed in eight beagles. After 2, 4, 12 and 24 weeks, implants were retrieved and prepared for histological observation, and the HA film thickness was determined using energy-dispersive X-ray spectroscopy. Light microscopy revealed that, after two weeks, the bone response to the HA-coated implants was much better than to the pure titanium implants, and osteoblasts were observed at the bone–implant interface. After four weeks, the screw threads of the HA-coated implants were almost completely covered with bone. The HA film thickness rapidly decreased up to four weeks of implantation, then gently decreased, reaching 0.40±0.03 μm at the upper region of the implant after 12 weeks. That indicates that about 80% of the HA film had dissolved after 12 weeks of implantation. The rate of decrease in the HA film thickness was greater with increasing implant depth.
Keywords: Sputtering, hydroxyapatite, dental implant
Journal: Bio-Medical Materials and Engineering, vol. 16, no. 4, pp. 243-251, 2006
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