Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC) – Structural investigations on two different carrier systems

Article type: Research Article

Authors: Saupe, Anne | Wissing, Sylvia A. | Lenk, Andreas | Schmidt, Corinna | Müller, Rainer H.^;

Affiliations: Department of Pharmaceutical Technology, Biotechnology & Quality Management, Kelchstr. 31, 12169 Berlin, Germany | dds – drug delivery services GmbH, Kronskamp 11, 24119 Kronshagen, Germany | Department of Structural Physics, TU Dresden, Mommsenstr. 13, 01069 Dresden, Germany

Note: [] Corresponding author. Tel.: +49 30 83850696; Fax: +49 30 83850616; E-mail: mpharma@zedat.fu-berlin.de.

Abstract: Two different types of colloidal lipid particles are presented and compared as innovative carrier systems. Size distribution and storage stability of formulations produced by hot high pressure homogenisation in lab and medium scale production were investigated by laser diffractometry (LD) and photon correlation spectroscopy (PCS). Nanoparticles were characterised by their melting and recrystallisation behaviour recorded by differential scanning calorimetry (DSC). Electron microscope investigations were also carried out showing the particulate character of these carriers. Reasons for observed differences in loading capacity are discussed and possibilities for dermal application are described.

Keywords: SLN, NLC, physical stability, loading capacity, particulate character, scaling up feasibility

Journal: Bio-Medical Materials and Engineering, vol. 15, no. 5, pp. 393-402, 2005