Affiliations: [a]
Department of Orthopaedics, Second Affiliated Hospital of Qiqihar Medical University, Qiqihar, China
| [b] Department of Orthopaedics, Affiliated Xinhua Hospital of Dalian University, Dalian, China
Correspondence:
[*]
Corresponding author: Nan Zhang, Department of Orthopaedics, Second Affiliated Hospital of Qiqihar Medical University, Qiqihar, 161000, China; and Department of Orthopaedics, Affiliated Xinhua Hospital of Dalian University, Dalian, 116001, China. E-mail: zhn1979-08@163.com
Abstract: BACKGROUND:Magnesium (Mg) alloy have biodegradation and mechanical properties that are similar to those of human bone, making it a promising candidate material for inclusion in implantable medical devices. OBJECTIVE:The osteointegration effect of Mg alloy scaffolds with different corrosion rates were studied and evaluated in large bone defect models. METHOD:Mg–Sr and Mg–Ca alloy scaffolds with a 20-μm Micro-arc oxidation (MAO) coating were used to repair critical bone defects for subsequent assessment of each alloy’s degradation and osteointegration by X-ray, Micro-CT, fluorescence and histological examination. RESULTS:At 12 weeks post-implantation, each defect was found to be effectively reconstructed by either of the Mg alloys based on X-ray and Micro-CT images. The corrosion rate (CR) of each Mg alloy – as calculated based on micro-computed tomography information – demonstrated that the MAO coating could provide effective protection for only 4 weeks post-surgery. From weeks 8 to 12, the CR of the Mg–Ca alloy scaffold increased from 1.34 ± 0.23 mm/y to 1.57 ± 0.16 mm/y. In contrast, the CR of the Mg–Sr alloy scaffold decreased from 0.58 ± 0.14 mm/y to 0.54 ± 0.16 mm/y. However, fluorescence and histological examination revealed more mature, closely and regularly arranged newborn osteocytes at the Mg–Ca scaffold-fracture interface e from weeks 8 to 12 after surgery. CONCLUSION:The Mg–Sr scaffold was more corrosion resistant and the Mg–Ca scaffold yielded a better overall repair, which indicates that the CR of magnesium alloys matches the rate of new bone formation and is the key to repair bone defects as a bone substitute.
