Affiliations: [a] Department of Biomedical Engineering, Faculty of Engineering, Helwan University, Cairo, Egypt
Correspondence:
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Corresponding author: Nancy M. Salem, Department of Biomedical Engineering, Faculty of Engineering, Helwan University, 1 Sherif Street, Helwan, Cairo, Egypt. E-mail: nancy_salem@h-eng.helwan.edu.eg
Abstract: Brain tumors are considered to be a leading cause of cancer death among young people. Early diagnosis is thus essential for treatment. The brain segmentation process is still challenging due to complexity and variation of the tumor structure, intensity similarity between tumor tissues and normal brain tissues. In this paper, a fully automated and reliable brain tumor segmentation system is proposed. This system is able to detect range of slices from a volume that is likely to contain tumor in MRI images. An iterated k-means algorithm is used for the segmentation process in conjunction with a cluster validity index to select the optimal number of clusters. The proposed approach is evaluated using simulated and real MRI of human brain from multimodal brain tumor image segmentation benchmark (BRATS) organized by MICCAI 2012 challenge. Our results achieved average for Dice overlap and Jaccard index for complete tumor region of 91.96% and 98.31% respectively when testing a set of 77 volumes. This shows the robustness of the new technique for clinical routine use.
Keywords: Brain tumor, MRI, image segmentation, k-means clustering, validity index
