Affiliations: [a] Department of Agricultural Engineering, Faculty of Engineering and Agro-Industry, Maejo University, Chiang Mai, Thailand | [b] Department of Mechanical Engineering, Faculty of Engineering, Chiang Mai University, Chiang Mai, Thailand
Correspondence:
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Corresponding author: Tipapon Khamdaeng, Department of Agricultural Engineering, Faculty of Engineering and Agro-Industry, Maejo University, Chiang Mai 50290, Thailand. Tel.: +66 5387 5000 15; Fax: +66 5387 5010; E-mail: tipapon@mju.ac.th
Abstract: The pulse wave velocity (PWV) has been shown to be associated with the properties of blood vessel and a cardiovascular risk factor such as aneurysm. The global PWV estimation is applied in conventional clinical diagnosis. However, the geometry of blood vessel changes along the wave traveling path and the global PWV estimation may not always detect regional wall changes resulting from cardiovascular diseases. In this study, a fluid structure interaction (FSI) analysis was applied on arch-shaped aortas with and without aneurysm aimed at determining the effects of the number of aneurysm, aneurysm size and the modulus ratio (aneurysm to wall modulus) on the pulse wave propagation and velocity. The characterization for each stage of aneurysmal aorta was simulated by progressively increasing aortic stiffness and aneurysm size. The pulse wave propagations and velocities were estimated from the two-dimensional spatial-temporal plot of the normalized wall displacement based on elastic deformation. The descending forward and arch reflected PWVs of aneurysmal aortic arch models were found up to 9.7% and 122.8%, respectively, deviate from the PWV of non-aneurysmal aortic arch model. The PWV patterns and magnitudes can be used to distinguish the characterization of the normal and aneurysmal aortic walls and shown to be relevant regional markers utilized in clinical diagnosis.
