Review of core-multishell nanostructured models for nano-biomedical and nano-biopharmaceutical application

Article type: Research Article

Authors: Šetrajčić–Tomić, Ana J.^a | Popović, Jovan K.^a | Vojnović, Matilda^{b; f} | Džambas, Ljubiša D.^c | Šetrajčić, Jovan P.^{d; e;}

Affiliations: [a] Department of Pharmacy, Medical Faculty, University of Novi Sad, Vojvodina, Serbia | [b] The Health Center, Novi Sad, Vojvodina, Serbia | [c] Department of Dentistry, Medical Faculty, University of Novi Sad, Vojvodina, Serbia | [d] Department of Physics, Faculty of Sciences, University of Novi Sad, Vojvodina, Serbia | [e] Faculty of Sports, Union – Nikola Tesla University, Belgrade, Serbia | [f] Medical Faculty, University of Novi Sad, Novi Sad, Serbia

Correspondence: [*] Corresponding author. E-mail: jovan.setrajcic@df.uns.ac.rs

Abstract: The main advantage of a theoretical approach is essential knowledge of the mechanisms that allow us to comprehend the experimental conditions that we have to fulfill to be able to get the desired results. Based on our research in ultrathin crystal structures performed so far, superlattices, Q-wires and Q-dots, we will consider the materials that can act as carriers for medicines and tagged substances. For this purpose we established a shell-model of ultrathin crystals and investigated their fundamental characteristics. This could be considered as a form of nano-engineering. In this paper we will analyze application of nanomaterials in biomedicine, that is to say we will present the recent accomplishments in basic and clinical nanomedicine. Achieving full potential of nanomedicine may be years or even decades away, however, potential advances in drug delivery, diagnosis, and development of nanotechnology-related drugs start to change the landscape of medicine. Site-specific targeted drug delivery (made possible by the availability of unique delivery platforms, such as dendrimers, nanoparticles and nanoliposomes) and personalized medicines (result of the advance in pharmacogenetics) are just a few concepts on the horizon of research. In this paper, especially, we have analyzed the changes in basic physical properties of spherical-shaped nanoparticles that can be made in several (nano)layers and have, at the same time, multiple applications in medicine. This paper presents a review of our current achievement in the field of theoretical physics of ultrathin films and possible ways to materialize the same in the field of nanopharmacy.

Keywords: Nanotechnology, nanomedicine, core-shells model, ultrathin film layers, drug deliveries

DOI: 10.3233/BME-181002

Journal: Bio-Medical Materials and Engineering, vol. 29, no. 4, pp. 451-471, 2018