Co-existence effect of tricalcium phosphate and bioactive glass on biological and biodegradation characteristic of Poly L-Lactic Acid (PLLA) in trinary composite scaffold form

Article type: Research Article

Authors: Ghasemi, Abbas^{; *} | Hashemi, Babak

Affiliations: Department of Materials Science and Engineering, School of Engineering, Shiraz University, Shiraz, Iran

Correspondence: [*] Corresponding author. Tel.: +98 917 262 6289; Fax: +98 21 884 98 824; E-mail: abbasghasemi@alum.sharif.ir.

Abstract: The purpose of this study is to analyze the co-existence effect of 30 wt.% TCP-BG phases on degradation and precipitation behaviors of PLLA based composite scaffold in biological media. First, phase separation method was used to synthesize of the pure PLLA and the trinary composite scaffolds, and second they were immersed in SBF solution for 45 days. Subsequently, the degradation and precipitation characteristic were investigated by analyzing of pH value and weight changes of the immersed samples, the ability of biological products formation and the change of relative molecular weight of PLLA matrix as function of the degradation time. Finally, the experimental data of relative molecular weight change were verified by Han and Pan model and comparisons were made between them. Results have represented precipitation of huge amount of carbonate apatite on surface of the composite scaffold, and also the acidity of SBF media changes moderately which is prove better bioactivity properties compare to the pure PLLA scaffold. The results of comparison with the model point to quiet good agreement between them in early stage of degradation. So, the consequences suggest that the TCP-BG/PLLA composite scaffold have great potential to be applied in bone replacements or repairs.

Keywords: Trinary composite scaffold, bio-degradation, modelling, carbonate apatite, tricalcium phosphate, bioactive glass

DOI: 10.3233/BME-171707

Journal: Bio-Medical Materials and Engineering, vol. 28, no. 6, pp. 655-669, 2017