Fibrotic infarction on the LV free wall may alter the mechanics of healthy septal wall during passive filling

Article type: Research Article

Authors: Nemavhola, Fulufhelo

Affiliations: Department of Mechanical and Industrial Engineering, College of science, Engineering and Technology, University of South Africa, Florida, 1710, South Africa. Tel.: +27 (0)11 471 2765; Fax: +27 (0)11 471 2963; E-mail: masitfj@unisa.ac.za

Abstract: The effect of myocardial infarction on the global functioning of the heart is well known. Less is understood regarding the effect of LV fibrotic infarction on the cardiac mechanics of the septal wall. To determine this unknown, the stress and strain of septal wall on the healthy and infarcted rat heart model is measured by using finite element models of rat heart geometries. The main objective of this study was to utilized computational methods to study the effect of LV free wall fibrotic infarction on the healthy septal wall. Three-dimensional biventricular rat heart geometries were developed from cardiac magnetic resonance images of a healthy heart and a heart with left ventricular (LV) fibrotic infarction after infarct induction. From these geometries, FE models were established. Three-dimensional biventricular rat heart geometries developed from cardiac magnetic resonance images were used in creating FE models of healthy and infarcted rat hearts. The average radial strain percentage change of the healthy septal wall on the epicardium, mid-wall and endocardium was 61%, 52% and 14% higher than the infarcted septal wall, respectively. It was concluded that the fibrotic infarction has a potential cause the malfunction of the heart due to high myocardial stress and strain that the septal wall experiences

Keywords: Finite element modeling, bi-ventricular heart model, computational mechanics, myocardial stress, myocardial strain

DOI: 10.3233/BME-171698

Journal: Bio-Medical Materials and Engineering, vol. 28, no. 6, pp. 579-599, 2017