Aging of bone marrow mesenchymal stromal/stem cells: Implications on autologous regenerative medicine

Issue title: Selected papers from the 6th China–France International Symposium “Stem Cells and Regenerative Medicine” and the first meeting of the France–China International CNRS Network (GDRI) CeSMeR, Nancy, 10–13 July 2016

Guest editors: J.-F. Stoltz, J. Magdalou and D. Bensoussan

Article type: Research Article

Authors: Charif, N.^{a; b} | Li, Y.Y.^{a; b} | Targa, L.^{a; b} | Zhang, L.^{b; d} | Ye, J.S.^{b; d} | Li, Y.P.^{b; e} | Stoltz, J.F.^{a; b; c} | Han, H.Z.^{b; f} | de Isla, N.^{a; b; *}

Affiliations: [a] CNRS-UL, UMR 7365, IMoPA, Faculté de Médecine, Vandoeuvre-lès-Nancy, France | [b] CNRS – GDRI 0851, France-Chine ≪ Stem cells and Regenerative medicine ≫ | [c] CHRU de Nancy, Unité de Thérapie Cellulaire et Tissulaire (UTCT) (FR CNRS-INSERM-UL-CHU), Vandoeuvre-Lès-Nancy, France | [d] Centre de Recherche Biomedicale, Calmette Hospital, Kunming, China | [e] College Médical, Université de Wuhan, Wuhan, Chine | [f] Centre de Recherche sur les cellules souches, Beijing et Tianjin, China

Correspondence: [*] Corresponding author. E-mail: natalia.de-isla@univ-lorraine.fr.

Abstract: With their proliferation, differentiation into specific cell types, and secretion properties, mesenchymal stromal/stem cells (MSC) are very interesting tools to be used in regenerative medicine. Bone marrow (BM) was the first MSC source characterized. In the frame of autologous MSC therapy, it is important to detect donor’s parameters affecting MSC potency. Age of the donors appears as one parameter that could greatly affect MSC properties. Moreover, in vitro cell expansion is needed to obtain the number of cells necessary for clinical developments. It will lead to in vitro cell aging that could modify cell properties. This review recapitulates several studies evaluating the effect of in vitro and in vivo MSC aging on cell properties.

Keywords: Mesenchymal stromal/stem cells, bone marrow, aging, regenerative medicine

DOI: 10.3233/BME-171624

Journal: Bio-Medical Materials and Engineering, vol. 28, no. s1, pp. S57-S63, 2017