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New designed nerve conduits with a porous ionic cross-linked alginate/chitisan structure for nerve regeneration

Issue title: Frontiers in Biomedical Engineering and Biotechnology – Proceedings of the 4th International Conference on Biomedical Engineering and Biotechnology, 18–21 August 2015, Shanghai, China

Guest editors: Feng Liu, Dong-Hoon Lee, Ricardo Lagoa and Sandeep Kumar

Article type: Research Article

Authors: Chaw, Jen-Raya | Liu, Hsia-Weib | Shih, Yu-Chaoc; d | Huang, Ching-Chengd; e; *

Affiliations: [a] Graduate Institute of Applied Science and Engineering, Fu Jen Catholic University, New Taipei City, Taiwan | [b] Department of Life Science, Fu Jen Catholic University, New Taipei City, Taiwan | [c] Department of Materials Science and Engineering, National Tsing-Hua University, Hsinchu, 30013, Taiwan | [d] Department of Biomedical Engineering, Ming-Chuan University, 5 De Ming Rd., Gui Shan District, Taoyuan, 333, Taiwan | [e] Metal Industries Research & Development Centre, 6F, No.162-24, Sec.3, Hsin-Yi Rd., Taipei 10658, Taiwan

Correspondence: [*] Address for correspondence: Ching-Cheng Huang, Department of Biomedical Engineering, Ming-Chuan University, 5 De Ming Rd., Gui Shan District, Taoyuan, 333, Taiwan. Tel.: +886-2-27013181EXT.114; Fax: +886-2-27085460; E-mail: jcchuang@mail.mirdc.org.tw.

Keywords: Cross-linking reaction, drug-release systems, composite

DOI: 10.3233/BME-151294

Journal: Bio-Medical Materials and Engineering, vol. 26, no. s1, pp. S95-S102, 2015

Published: 2015
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A new fabrication process for designing nerve conduits with a porous ionic cross-linked alginate/chitosan composite for nervous regeneration could be prepared. New designed nerve conduits with a porous ionic cross-linked alginate/chitosan composite were developed for nervous regeneration. Nerve conduits (NCs) represent a promising alternative to conventional treatments for peripheral nerve repair. NCs composed of various polysaccharides such as sodium alginate were designed and prepared by lyophilization as potential matrices for tissue engineering. The use of a porous ionic cross-linked alginate/chitosan composite could provide penetration channels that would lead to the products’ increasing penetration rate properties. Furthermore, the use of a porous ionic cross-linked alginate/chitosan composite also has a highly cross-linked structure, which would give the products relatively good mechanical properties. Furthermore, the drug could be incorporated into nerve conduits as a new drug-carrying system for nerve regeneration because of its porous and cross-linked structures.

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