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Early detection of subjective memory impairment in Parkinson's disease using cerebral perfusion SPECT

Issue title: Frontiers in Biomedical Engineering and Biotechnology – Proceedings of the 3rd International Conference on Biomedical Engineering and Biotechnology, 25–28 September 2014, Beijing, China

Article type: Research Article

Authors: Song, In-Uk | Kim, Joong-Seok | Chung, Sung-Woo | Lee, Kwang-Soo | Oh, Jin-Kyoung | Chung, Yong-An;

Affiliations: Department of Neurology, College of Medicine, The Catholic University of Korea, Seocho-gu, Banpo-dong 505 Seoul, 137-701, Korea | Department of Radiology, College of Medicine, The Catholic University of Korea, Seocho-gu, Banpo-dong 505 Seoul, 137-701, Korea

Note: [] Corresponding author: Yong-An Chung, Department of Radiology, Incheon St. Mary's Hospital, The Catholic University of Korea, #56 Dongsu-ro, Bupyeong-gu, Incheon, 403-720, Korea. Tel.: 82-32-280-5243; Fax: 82-32-280-5244; E-mail: nm@catholic.ac.kr.

Keywords: Parkinson's disease, subjective memory impairment, perfusion SPECT

DOI: 10.3233/BME-141164

Journal: Bio-Medical Materials and Engineering, vol. 24, no. 6, pp. 3405-3410, 2014

Published: 2014
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Abstract

Cognitive dysfunction is a common feature of Parkinson's disease (PD). Recent research has focused on the detection and management of subjective memory impairment (SMI) as the stage that precedes mild cognitive impairment (MCI). Nevertheless, few clinical studies have biomarkers of SMI in PD. Therefore, this study was designed to investigate differences in perfusion brain SPECT between PD with SMI (PD+SMI) and PD without SMI (PD-SMI) to identify a potential prodromal biomarker of progression to dementia in patients with PD. In this study, 30 PD patients with SMI and 24 PD patients without SMI have been recruited. All subjects underwent perfusion brain SPECT and neuropsychological testing. Brain SPECT images were analyzed by using the SPM program and comparing between patients with PD+SMI and PD-SMI. The PD+SMI and PD-SMI groups did not differ in any neuropsychological tests, except for MMSE. Despite a significant difference in MMSE scores, all scores of both groups were in the normal range. Brain SPECT analysis of PD+SMI patients showed hypoperfusion in the frontal and inferior temporal regions, anterior cingulate and thalamus compared with PD-SMI patients. This pilot study investigated the role of decreased brain perfusion SPECT findings in PD+SMI patients compared with PD-SMI patients as a predictive biomarker of pre-dementia as the stage that precedes MCI in PD. Larger, prospective studies are warranted for further investigation of the pathophysiology of neuronal systems during cognitive decline.

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