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Osteoarthritis and psoriatic arthritis: Findings in three-dimensional biophotonics imaging

Issue title: Frontiers in Biomedical Engineering and Biotechnology – Proceedings of the 3rd International Conference on Biomedical Engineering and Biotechnology, 25–28 September 2014, Beijing, China

Article type: Research Article

Authors: Yuan, Zhen; | Ieong, Fong H. | Jiang, Huabei | Sobel, Eric S.

Affiliations: Bioimaging Core, Faculty of Health Sciences, University of Macau, Macau SAR, China | Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA | Division of Rheumatology, College of Medicine, University of Florida, Gainesville, FL 32611, USA

Note: [] Corresponding author: Zhen Yuan, Director of Bioimaging Core, Faculty of Health Sciences, University of Macau, Macau SAR, China. Tel.: 853-88224989; Fax: 853-8822-2314; E-mail: zhenyuan@umac.mo.

Keywords: diffuse optical tomography, osteoarthritis, psoriatic arthritis, x-ray

DOI: 10.3233/BME-141128

Journal: Bio-Medical Materials and Engineering, vol. 24, no. 6, pp. 3063-3071, 2014

Published: 2014
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Abstract

The goal of this study is to capture the quantitative optical features of degenerative finger joints based on x-ray aided three-dimensional (3D) diffuse optical tomography (DOT). It is anticipated that the fused imaging technique can be applied to identifying the significant differences between osteoarthritis (OA) and psoriatic arthritis (PA). For a case study, total 6 subjects were selected to study the distal interphalangeal (DIP) finger joints. 2 OA patients, 2 PA patients and 2 healthy subjects were examined clinically first. Their DIP finger joints were then scanned by the multimodality imaging method. Our findings suggested that the developed multimodality imaging approach may aid to contradistinguish OA patients from PA patients with the healthy control, which is essential for a better diagnosis and treatment of inflammatory arthritis in humans.

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