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Dielectric properties of human liver from 10Hz to 100MHz: normal liver, hepatocellular carcinoma, hepatic fibrosis and liver hemangioma

Issue title: Frontiers in Biomedical Engineering and Biotechnology – Proceedings of the 3rd International Conference on Biomedical Engineering and Biotechnology, 25–28 September 2014, Beijing, China

Article type: Research Article

Authors: Wang, Hang; | He, Yong | Yang, Min | Yan, Qingguo | You, Fusheng | Fu, Feng | Wang, Ting | Huo, Xuyang | Dong, Xiuzhen; | Shi, Xuetao;

Affiliations: Department of Biomedical Engineering, Fourth Military Medical University, No. 169 Changle West Road, 710032, Xi'an, China | Xijing Hospital, Fourth Military Medical University, No. 169 Changle West Road, 710032, Xi'an, China | Department of Pathology, Fourth Military Medical University, No. 169 Changle West Road, 710032, Xi'an, China

Note: [] Hang Wang and Yong He are thought to have equal contributions. Moreover, the authors declare that there is no conflict of interests regarding the publication of this paper.

Note: [] Xiuzhen Dong, Department of Biomedical Engineering, Fourth Military Medical University, No. 169 Changle West Road, 710032, Xi'an, China. Tel.: +8602984776397; Fax: +8602984776397; E-mail: dongxiuzhen@fmmu.edu.cn.

Note: [] Corresponding authors: Xuetao Shi, Department of Biomedical Engineering, Fourth Military Medical University, No. 169 Changle West Road, 710032, Xi'an, China. Tel.: +8602984774848; Fax: +8602984774848; E-mail: shixuetao@fmmu.edu.cn.

Keywords: Dielectric property, characteristic parameters, liver cancer, hepatic fibrosis

DOI: 10.3233/BME-141090

Journal: Bio-Medical Materials and Engineering, vol. 24, no. 6, pp. 2725-2732, 2014

Published: 2014
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Abstract

The dielectric properties of human liver were determined by characterization of tissue absorption and coupling of electromagnetic energy in the electromagnetic field. In this study the ex-vivo dielectric properties of human hepatocellular carcinoma (well and moderately differentiated), liver hemangioma, hepatic fibrosis (stages S1 and S2), and normal liver tissue were measured and analyzed over the frequency range of 10 Hz to 100 MHz. The dielectric properties over the frequency range can reflect tissue information including biological macromolecules, vesicles, and cellular membrane; these information aids in distinguishing different physiological states and lesions. The ex-vivo conductivity, permittivity, resistivity, as well as the characteristic parameters between the lesions and normal liver were analyzed and their differences were also verified. The data can contribute to developing bioelectric applications for tissue diagnostics and creating more accurate computer models for medical applications.

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