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A three-dimensional numerical simulation of cell behavior in a flow chamber based on fluid-solid interaction

Issue title: Frontiers in Biomedical Engineering and Biotechnology – Proceedings of the 3rd International Conference on Biomedical Engineering and Biotechnology, 25–28 September 2014, Beijing, China

Article type: Research Article

Authors: Bai, Long | Cui, Yuhong; | Zhang, Yixia | Zhao, Na

Affiliations: Department of Mechanics, Tianjin University, Tianjin, China | School of Engineering and Information Technology, UNSW Canberra, Canberra, Australia

Note: [] Corresponding author: Yuhong Cui, Department of Mechanics, Tianjin University, Tianjin, China. Tel.: +86-22-27404934; Fax: +86-22-27403754; E-mail: yhcui@tju.edu.cn.

Keywords: Fluid-solid interaction, numerical simulation, jumping, rolling, deformation

DOI: 10.3233/BME-141081

Journal: Bio-Medical Materials and Engineering, vol. 24, no. 6, pp. 2645-2655, 2014

Published: 2014
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Abstract

The mechanical behavior of blood cells in the vessels has a close relationship with the physical characteristics of the blood and the cells. In this paper, a numerical simulation method was proposed to understand a single-blood cell's behavior in the vessels based on fluid-solid interaction method, which was conducted under adaptive time step and fixed time step, respectively. The main programme was C++ codes, which called FLUENT and ANSYS software, and UDF and APDL acted as a messenger to connect FLUENT and ANSYS for exchanging data. The computing results show: (1) the blood cell moved towards the bottom of the flow chamber in the beginning due to the influence of gravity, then it began to jump up when reached a certain height rather than touching the bottom. It could move downwards again after jump up, the blood cell could keep this way of moving like dancing continuously in the vessels; (2) the blood cell was rolling and deforming all the time; the rotation had oscillatory changes and the deformation became conspicuously when the blood cell was dancing. This new simulation method and results can be widely used in the researches of cytology, blood, cells, etc.

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