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A fluid-particle interaction method for blood flow with special emphasis on red blood cell aggregation

Issue title: Frontiers in Biomedical Engineering and Biotechnology – Proceedings of the 3rd International Conference on Biomedical Engineering and Biotechnology, 25–28 September 2014, Beijing, China

Article type: Research Article

Authors: Wang, Tong; | Xing, Zhongwen

Affiliations: Department of Mathematics, Nanjing University of Aeronautics and Astronautics Nanjing, Jiangsu, 210016, China | Department of Materials Science and Engineering, National Laboratory of Solid State Microstructures, Nanjing University, Nanjing, Jiangsu, 210093, China

Note: [] Corresponding author: Tong Wang, Department of Mathematics, Nanjing University of Aeronautics and Astronautics, 29 Yudao Street, Nanjing, Jiangsu, 210016, China. Tel.: +86 25 84892440; Fax: +86 25 84498069; E-mail: twang@nuaa.edu.cn.

Keywords: Fluid-particle interaction, red blood cells, aggregation, mathematical modelling

DOI: 10.3233/BME-141065

Journal: Bio-Medical Materials and Engineering, vol. 24, no. 6, pp. 2511-2517, 2014

Published: 2014
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Abstract

This paper presents a fluid-particle interaction algorithm using the distributed Lagrange multiplier based fictitious domain method. The application of this method to the numerical investigation of motion and aggregation of red blood cells in two-dimensional microvessels is discussed. The cells are modelled as rigid biconcave-shaped neutrally buoyant particles. The aggregating force between two cells is derived from a Morse type potential function. The cell-cell interaction is coupled with the fluid-cell interaction through a time splitting scheme. Simulation results of multiple red blood cells in Poiseuille flow are presented. Because of its modular nature, this algorithm is applicable to a large class of problems involving the processes of particle aggregation and fluid-particle interaction.

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