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Quantitative evaluation of parkinsonian rigidity during intra-operative deep brain stimulation

Issue title: Frontiers in Biomedical Engineering and Biotechnology – Proceedings of the 3rd International Conference on Biomedical Engineering and Biotechnology, 25–28 September 2014, Beijing, China

Article type: Research Article

Authors: Kwon, Yuri | Park, Sang-Hoon | Kim, Ji-Won | Ho, Yeji | Jeon, Hyeong-Min | Bang, Min-Jung | Koh, Seong-Beom; | Kim, Jong-Hyun | Eom, Gwang-Moon; ;

Affiliations: School of Biomedical Engineering, Konkuk University, Choonju, 380-701, Korea | Research Institute of Biomedical Engineering, Konkuk University, Choonju, 380-701, Korea | Department of Neurology, Korea University College of Medicine, Seoul, Korea | Department of Neurosurgery, Korea University College of Medicine, Seoul, Korea

Note: [] Corresponding authors: Seong-Beom Koh, Department of Neurology, Korea University College of Medicine, Seoul, Korea. Tel.: +82-2-2626-3169; E-mail: parkinson@korea.ac.kr.

Note: [] Gwang-Moon Eom, Research Institute of Biomedical Engineering, Konkuk University, Choonju, 380-701, Korea. Tel.: +82-43-840-3766; Fax: +82-43-851-0620; E-mail: gmeom@kku.ac.kr.

Keywords: Intraoperative, quantification, rigidity, DBS surgery, Parkinson's disease

DOI: 10.3233/BME-141040

Journal: Bio-Medical Materials and Engineering, vol. 24, no. 6, pp. 2273-2281, 2014

Published: 2014
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Abstract

This study aims at the quantification of fine change in parkinsonian rigidity at the wrist during deep brain stimulation (DBS) using a portable measurement system and objective mechanical measures. The rigidity of fourteen limbs was evaluated during DBS surgery. The resistive torque to imposed movement was measured for every setting where a reduction in rigidity was perceived by a neurologist. Quantitative mechanical measures derived from experimental data included viscoelastic properties, work, impulse and mechanical impedance. Most mechanical measures could discriminate the optimal setting from baseline (electrode at stereotactic initial position without electrical stimulation) and the highest significance was achieved by viscous damping constant (p<0.001). Spearman correlation coefficients between mechanical measures and clinical score for multiple settings (averaged for 14 limbs) were 0.51–0.77 and the best correlation was shown for viscosity (ρ=0.77±0.22). The results suggest that intraoperative quantification of rigidity during DBS surgery is possible with the suggested system and measures, which would be helpful for the adjustment of electrode position and stimulation parameters.

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