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Stem cells from human exfoliated deciduous teeth differentiate into functional hepatocyte-like cells by herbal medicine

Issue title: Frontiers in Biomedical Engineering and Biotechnology – Proceedings of the 3rd International Conference on Biomedical Engineering and Biotechnology, 25–28 September 2014, Beijing, China

Article type: Research Article

Authors: Su, Wen-Ta; | Chen, Xiao-Wei

Affiliations: Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, 1 Sec. 3, Chung-Hsiao E. Rd, Taipei 10608, Taiwan

Note: [] Corresponding author: Wen-Ta Su, Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, 1 Sec. 3, Chung-Hsiao E. Rd, Taipei 10608, Taiwan. Tel.: +886-2-27712171 ext. 2554; Fax: +886-2-27519204; E-mail: f10549@ntut.edu.tw

Keywords: SHEDs, liquorice, angelica, differentiation, hepatocytes

DOI: 10.3233/BME-141036

Journal: Bio-Medical Materials and Engineering, vol. 24, no. 6, pp. 2243-2247, 2014

Published: 2014
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Abstract

Stem cells from human exfoliated deciduous teeth (SHEDs) are mesenchymal stem cells isolated from the exfoliated human deciduous incisor that can differentiate into a many cell types. In this study, we evaluated the effect of liquorice or angelica extracts on the hepatic differentiation potential of SHEDs cells. SHEDs cells cultured in medium containing liquorice extracts were analyzed for 1) changes in cellular morphology, 2) changes in hepatic gene expression, AFP (Alpha-fetoprotein) and ALB (Albumin), and 3) albumin secretion and urea synthesis activity. Our data show that the hepatic differentiation potential of SHEDs cells is enhanced by the presence of liquorice or angelica extracts in the culture medium. Our findings present new therapeutic possibilities for liver damage repair.

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