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Designed drug-release systems having various breathable polyurethane film-backed hydrocolloid acrylated adhesive layers for moisture healing

Issue title: Frontiers in Biomedical Engineering and Biotechnology – Proceedings of the 3rd International Conference on Biomedical Engineering and Biotechnology, 25–28 September 2014, Beijing, China

Article type: Research Article

Authors: Chang, Ching-Hsien; | Liu, Hsia-Wei | Huang, Ching-Cheng; ;

Affiliations: Department of Chinese Medicine, En Chu Kong Hospital, New Taipei City, Taiwan | Department of Cosmetic Science, Chang Gung University of Science and Technology, Taoyuan, Taiwan | Department of Life Science, Fu Jen Catholic University, New Taipei City, Taiwan | Department of Biomedical Engineering, Ming-Chuan University, Taoyuan, Taiwan | Regional R&D Service Department, Metal Industries Research & Development Centre, Taipei, Taiwan

Note: [] Corresponding author: Ching-Cheng Huang, Department of Biomedical Engineering, Ming-Chuan University, 5 De Ming Rd., Gui Shan District, Taoyuan, 333, Taiwan. Tel.: +886-988-915-063; Fax: +886-3-359-3840; E-mail: jcchuang@mail.mirdc.org.tw.

Keywords: Hydrocolloid, drug-release systems, breathable, carbomer

DOI: 10.3233/BME-141018

Journal: Bio-Medical Materials and Engineering, vol. 24, no. 6, pp. 2081-2088, 2014

Published: 2014
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Abstract

A series of designed drug-release systems were prepared and established for clear moisture healing. These systems were designed to have an interpenetrating polymer network (IPN) structure, which contained a breathable polyurethane film, hydrocolloidlayer, and polyacrylate adhesive layer. Breathable polyurethane film (2000 g/m2/24 hr) with high moisture permeability was employed as a base for new drug-release systems or wound dressings. All drug-release systems having a polyurethane film-backed hydrocolloid acrylated adhesive layer showed an increase of water uptakes with increasing time. After 114 hours, high water uptakes of drug-release systems with 20% hydrocolloid components were observed in the values of 160, 1100, and 1870% for different additional hydrocolloid components of carboxymethylcellulose, sodium alginate, and carbomer U10, respectively. New drug-release systems of polyurethane film-backed hydrocolloid/adhesive layers could be designed and established for wound care managements.

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