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Characterization of a co-electrospun scaffold of HLC/CS/PLA for vascular tissue engineering

Issue title: Frontiers in Biomedical Engineering and Biotechnology – Proceedings of the 3rd International Conference on Biomedical Engineering and Biotechnology, 25–28 September 2014, Beijing, China

Article type: Research Article

Authors: Zhu, Chenhui; | Ma, Xiaoxuan; | Xian, Li; | Zhou, Yang; | Fan, Daidi; ;

Affiliations: Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi'an, Shaanxi 710069, China | Shaanxi R & D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi'an, Shaanxi 710069, China

Note: [] Corresponding author: Daidi Fan, Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi'an, Shaanxi 710069, China. Tel.: 13809193640; Fax: 029-88302223; E-mail: fandaidi@nwu.edu.cn.

Keywords: Tissue engineering, blood vessel scaffold, co-electrospinning, biocompatibility

DOI: 10.3233/BME-141009

Journal: Bio-Medical Materials and Engineering, vol. 24, no. 6, pp. 1999-2005, 2014

Published: 2014
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Abstract

Novel scaffolds for vascular tissue engineering were fabricated by co-electrospinning human-like collagen/chitosan and polylactic acid at room temperature and normal pressure. By studying the effects of composition and collecting distance on the morphology of electrospun meshes, we determined that the proper collecting distance and the concentration of the solution are the keys to the success of the co-electrospinning process. The scaffolds were characterized by scanning electron microscopy (SEM) and distribution of the fibrous diametrs was analyzed. Also, Hemocompatibility of the scaffolds were evaluated. The results indicated that scaffolds fabricated by co-electrospinning: (1) had a more biomimetic structure than polylactic acid, as the fiber diameters approached the size of the extracellular matrix; (2) showed better hemocompatibility. This study demonstrates the feasibility of using two different solutions to construct a scaffold for blood vessel tissue engineering by co-electrospinning.

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