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Article type: Research Article
Authors: Lenne, Bruno; | Blanc, Jean-Luc | Nandrino, Jean-Louis | Gallois, Philippe | Hautecæur, Patrick | Pezard, Laurent
Affiliations: Service de Neurologie, Hôpital Universitaire Saint-Philibert – GHICL, Lomme, France | INS, UMR 1106 Inserm, Aix-Marseille Université, Marseille, France | URECA EA 1059, Université de Lille Nord de France, Lille, France
Note: [] Corresponding author: Laurent Pezard, INS, UMR 1106 27 Bd Jean Moulin, 13385 Marseille {Cedex} 05, France. E-mail: laurent.pezard@univ-amu.fr
Abstract: The disturbance of cortical communication has been hypothesized as an important factor in the appearance of cognitive impairment in (MS). Cortical communication is quantified here in control subjects and patients with relapsing-remitting multiple sclerosis (RRMS) on the basis of mean coherence in the δ, �, α, β and γ bands and using mutual information computed between pairs of bipolar EEG signals recorded during resting condition. Each patient received also a cognitive assessment using a battery of neuropsychological tests specific to cognitive deficits in MS. No difference was observed for the coherence indices whereas inter-hemispheric and right hemisphere mutual information is significantly lower in patients with MS than in control subjects. Moreover, inter-hemispheric mutual information decrease significantly with illness duration and right mutual information differentiate cognitively deficient and non-deficient patients. Mutual information allows to quantify the cortical communication in patients with RRMS and is related to clinical characteristics. Cortical communication quantified in a resting state might be a potential marker for the neurological damage induced by RRMS.
Keywords: Multiple sclerosis, EEG signals, mutual information, coherence, inter-hemispheric communication
DOI: 10.3233/BEN-120278
Journal: Behavioural Neurology, vol. 27, no. 2, pp. 201-212, 2013
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