Affiliations: Department of Neuropsychiatry, Raúl Carrea Institute of Neurological Research, Buenos Aires, Argentina | Department of Clinical Neurology, Raúl Carrea Institute of Neurological Research, Buenos Aires, Argentina | Department of Nuclear Medicine, Raúl Carrea Institute of Neurological Research, Buenos Aires, Argentina
Note: [] Correspondence to: S.E. Starkstein, FLENI, Montañeses 2325, 1428 Buenos Aires, Argentina
Note: [] This article originally appeared in European Journal of Neurology (1997), 4, 231–236.
Abstract: We examined, with single photon emission tomography (SPECT) and (99mTc)-HMPAO, 18 patients with idiopathic Parkinson's disease and no dementia (PD), 12 patients with PD and dementia, 24 patients with probable Alzheimer's disease (AD), and 14 controls. While the three patient groups showed significantly lower perfusion in frontal inferior and temporal inferior areas as compared to controls, both demented groups showed significantly more severe bilateral hypoperfusion in superior frontal, superior temporal and parietal areas as compared to non-demented PD patients and controls. On the other hand, no significant differences in cerebral perfusion were found between patients with AD and patients with PD and dementia. In conclusion, our findings demonstrated specific but similar cerebral perfusion deficits in demented patients with either AD or PD.
