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Article type: Research Article
Authors: Öztürk, Candan | Özge, Aynur | Yalın, Osman Özgür | Yılmaz, İ. Arda | Delialioglu, Nuran | Yıldız, Çilem | Tesdelen, Bahar | Kudiaki, Cigdem
Affiliations: Mersin University School of Medicine and Mersin University School of Science and Letters, Mersin, Turkey
Note: [] Corresponding author: Aynur Özge, Associate Professor of Neurology, Mersin University School of Medicine, Mersin, Turkey. Tel.: +90 324 3598904; Fax: +90 324 3594336; E-mail: aozge@mersin.edu.tr or aynurozge@gmail.com
Abstract: In the past years, the possible involvement of inflammation in the pathogenesis of dementia has been the subject of several investigations. However there are restricted data about the profile of the inflammatory and soluble proteins in well evaluated Alzheimer's disease (AD), vascular dementia (VD), mild cognitive impairment (MCI) and healthy controls. There are also no reliable data regarding the relationship between the overlapping protein levels and cognitive or functional decline. We measured levels of IL-1β, IL-2, IL-6, IL-18, TNF-α, β-Amlyloid 1–40 and α _1-antichymotrypsin levels in plasma in groups of total 82 subjects with AD, MCI, VD and controls using enzyme-linked immunosorbent assay (ELISA) method. Our study samples showed high levels of proinflammatory cytokine levels (especially IL-18) in all patient groups but only high levels of α_1-antichymotrypsine in VD patients compared to controls. There is no significant correlation between the laboratory and clinical variables except for a link between IL-1β and NPI scores of AD. In conclusion, this study yielded evidence of some shared mechanisms underlying AD and VD and thus motivates further studies of inflammatory markers in various types of dementia and MCI.
Keywords: Alzheimer's disease (AD), vascular dementia (VD), mild cognitive impairment (MCI), cognitive decline, functional decline, inflammatory, cytokine, soluble protein
Journal: Behavioural Neurology, vol. 18, no. 4, pp. 207-215, 2007
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