Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Camarda, Rosolino | Camarda, Cecilia | Monastero, Roberto | Grimaldi, Silvia | Camarda, Lawrence K.C. | Pipia, Carmela | Caltagirone, Carlo | Gangitano, Massimo
Affiliations: Laboratory of Epidemiology and Psychology of Aging and Dementia, Section of Neurology, Department of Clinical Neuroscience, University of Palermo, Palermo, Italy | Department of Neurology, University "Tor Vergata", and Fondazione "Santa Lucia" IRCCS, Rome, Italy
Note: [] Address for correspondence: Prof. Rosolino Camarda, LEPAD, Sezione di Neurologia, Dipartimento di Neuroscienze Cliniche, Università di Palermo, Via G. La Loggia, 1, 90129, Palermo, Italy. Tel.: +39 091 655 51 12; Fax: +39 091 655 51 13; E-mail: rosolino.camarda@unipa.it
Abstract: We evaluated the relationship between motor and neuropsychological deficits in subjects affected by amnestic Mild Cognitive Impairment (aMCI) and {early} Alzheimer's Disease (AD). Kinematics of goal-directed movement of aMCI and AD subjects were compared to those of age-matched control subjects. AD showed a slowing down of motor performance compared to aMCI and controls. No relationships were found between motor and cognitive performances in both AD and aMCI. Our results suggest that the different motor behaviour between AD and aMCI cannot be related to memory deficits, probably reflecting the initial degeneration of parietal-frontal circuits for movement planning. The onset of motor dysfunction in early AD could represent the transition from aMCI to AD.
Keywords: Alzheimer's Disease, Mild Cognitive Impairment, kinematics, pointing, neuropsychology
Journal: Behavioural Neurology, vol. 18, no. 3, pp. 135-142, 2007
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
sales@iospress.com
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
info@iospress.nl
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office info@iospress.nl
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
china@iospress.cn
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
如果您在出版方面需要帮助或有任何建, 件至: editorial@iospress.nl