Affiliations: School of Chemical and Environmental Engineering,
Shanghai Institute of Technology, Shanghai 201418, PR China | Department of Environmental Science, East China Normal
University, Shanghai 200241, PR China | Key Laboratory of Urban Agriculture (South) of
Ministry of Agriculture, School of Agriculture and Biology, Shanghai Jiao Tong
University, Shanghai 200240, PR China
Abstract: Veterinary antibiotics have been used extensively in many countries
to treat diseases and protect the health of animals. As they are poorly
adsorbed in the gut of the animals, the majority of antibiotics are excreted
unchanged in faeces and urine. Therefore, antibiotic contaminants in aquatic
ecosystems may pose physiological effects on aquatic lives. In the present
study, growth inhibition and oxidative damage in cyanobacteria Microcystis
aeruginosa exposed to doxycycline hydrochloride were investigated. The results
showed that doxycycline hydrochloride could inhibit the growth of M. aeruginosa
under laboratory conditions. The inhibition percentages after 24 h, 48 h, 72 h
and 96 h exposure at the concentration of 1 mg/L were 8.13%, 16.49%, 39.56% and
55.31%, respectively. The activities of superoxide dismutase (SOD), catalase
(CAT), and the concentrations of malondialdehyde (MDA) in M. aeruginosa were
stimulated by doxycycline hydrochloride after 24 h exposure under a series of
concentrations. The results are useful for environmental assessment of
antibiotics. Besides, it is also helpful for guiding the application of
doxycycline hydrochloride in agricultural settings.
