BRAF in papillary thyroid carcinoma

Article type: Research Article

Authors: Lanzilotta, Salvatore Giovanni | Grammatica, Luciano | Paradiso, Angelo | Simone, Gianni

Note: [] Corresponding author: Gianni Simone, MD, Istituto Tumori “Giovanni Paolo II”, via Hanhemann 10, 70126 Bari, Italy. Tel.: +39 080 5555544; Fax: +39 0805555561; E-mail: g.simone@oncologico.bari.it.

Abstract: Novel genetic findings about papillary thyroid carcinoma identify BRAF gene as a subject of great interest. Involvement of BRAF gene in pathogenesis of PTC, diagnostic value and the putative prognostic significance of its T1799A mutation are summarized in this article. Furthermore, a particular attention is focused to the role of pre-operative detection of BRAF mutation in the FNAB specimens of thyroid nodules and to the use of this gene as target for an effective cancer therapy.

Keywords: BRAF mutation, papillary thyroid cancer, fine-needle aspiration

Journal: Analytical Cellular Pathology, vol. 29, no. 4, pp. 269-277, 2007