Affiliations: Department of Integrative Medicine and Neurobiology, National Key lab of Medical Neurobiology, Institute of Brain Research Sciences, Shanghai Medical College, Fudan University, Shanghai, P.R. China
Note: [] Correspondence to: Hui Zhao, Department of Integrative Medicine and Neurobiology, Shanghai Medical College, Fudan University, 138# Yixueyuan Rd. Box 291, Shanghai, 200032, P.R. China. Tel.: +86 21 54237611; Fax:+86 21 54237023; E-mail: zhaohui07054@fudan.edu.cn
Abstract: c-Src/Fyn, a non-receptor type tyrosine kinase, which is expressed by virtually all cells with very high expression levels found in neurons, suggesting a role in brain function. Lately, Src was found to be related to neuron-glia modulation, and the appreciable functions were found not only located at the plasma membrane but also in variety of intracellular locations. Besides that, Src could coordinate with other signal molecules and operated as molecular switches in synaptic cellular communication in response to brain injury. Src activation was also characterized to be required for conveying the recovery signals from immuno-suppression, the regulatory networks involved the interaction between Src and mu opioid receptor, EGFR, IGF and IL-1β. Therefore, Src signaling was proposed to be the important therapeutic consideration regarding neuroimmune modulation in response to brain injury.
Keywords: c-Src, Fyn, signal transduction, neuro-immune modulation
