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Inflammatory Hyperalgesia: The Role of the Prostaglandin System in the Spinal Cord

Issue title: Dopamine in Immunoregulation

Article type: Research Article

Authors: Fujikawa, Megumi | Ibuki, Takae | Matsumura, Kiyoshi | Sawa, Teiji

Affiliations: Department of Anesthesiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan | Department of Biomedical Engineering, Osaka Institute of Technology, Osaka, Japan

Note: [] Correspondence to: Megumi Fujikawa, Department of Anesthesiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi - Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan. Tel.: +81 75 2515633; Fax: +81 75 2515843; E-mail: m-fuji@koto.kpu-m.ac.jp

Keywords: Inflammation, hyperalgesia, cytokine, prostaglandin, cyclooxygenase-2, spinal cord

DOI: 10.3233/NIB-2012-012041

Journal: Advances in Neuroimmune Biology, vol. 3, no. 2, pp. 197-207, 2012

Published: 2012
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Abstract

Hyperalgesia is a symptom often associated with inflammation. The essential role of prostaglandins (PG) in hyperalgesia has long been known since the early 1970 s. Molecular identification of PG receptors and PG-synthesizing enzymes in the late 1980 s/early 1990 s has greatly advanced the understanding of inflammatory hyperalgesia. In this review, we provide an overview of the PG system in the spinal cord, focusing on its relevance to inflammatory hyperalgesia.

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