Affiliations: [a] Department of Biomedical Laboratory Science, Kyungwoon University, Gumi, Korea | [b] Department of Dental Hygiene, Konyang University, Daejeon, Korea
Correspondence:
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Corresponding author: Kyung-Hee Kang, Department of Dental Hygiene, Konyang University, Daejeon, Korea. E-mail:dhkhkang@konyang.ac.kr
Abstract: We investigated the burdock extract on the inhibitions of NO
generation, COX-2 expression, and the generations of IL-6 and TNF-α ,
to find out its anti-inflammatory effect in this study. After the treatment
of the burdock extract in the cells, we measured the amount of NO generated
in the inflammatory cells developed by LPS and UVB, and confirmed the
developments of inflammatory mediators by RT-PCR. Upon the results on the NO
generation after the development of inflammation by LPS in Raw 264.7 cell,
we found approximately 50% of inhibitory effect at 200 μg/ml
concentrations of the burdock extract. It was confirmed that the expression
levels of TNF-α, COX-2, and IL-6 were declined to the levels of
control by LPS and UVB stimulated inflammation in HaCat cell. This means the
anti-inflammatory effect of the burdock extract.
