Inflammation and NF-κB in Alzheimer's Disease and Diabetes

Issue title: Oxidative Stress, Reactive Metabolites, Inflammation, and RAGE – Building a Bridge from Alzheimer's Disease to Diabetes and Vice Versa

Guest editors: Angelika Bierhaus

Article type: Research Article

Authors: Granic, Ivica^{a; 1} | Dolga, Amalia M.^{b; 1} | Nijholt, Ingrid M.^a | van Dijk, Gertjan^c | Eisel, Ulrich L.M.^{a; *}

Affiliations: [a] Department of Molecular Neurobiology, University of Groningen, Haren, The Netherlands | [b] Department of Pharmacology and Toxicology, Philipps-University Marburg, Germany | [c] Department of Neuroendocrinology, University of Groningen, Haren, The Netherlands

Correspondence: [*] Corresponding author: Ulrich L.M. Eisel, Department of Molecular Neurobiology, University of Groningen, P.O. Box 14, 9750 AA Haren, The Netherlands. Tel.: +31 503 632357; Fax: +31 503 632331; E-mail: U.L.M.Eisel@rug.nl.

Note: [1] These authors contributed equally to this work.

Abstract: Inflammatory processes are a hallmark of many chronic diseases including Alzheimer's disease and diabetes mellitus. Fairly recent statistical evidence indicating that type 2 diabetes increases the risk of developing Alzheimer's disease has led to investigations of the potential common processes that could explain this relation. Here, we review the literature on how inflammation and the inducible nuclear factor NF-κB might be involved in both diabetes mellitus and Alzheimer's disease and whether these factors can link both diseases.

Keywords: Alzheimer's disease, inflammation, insulin, insulin-degrading enzyme, nuclear factor-κB, receptor for advanced glycation endproducts (RAGE), tumor necrosis factor, type 2 diabetes mellitus

DOI: 10.3233/JAD-2009-0976

Journal: Journal of Alzheimer's Disease, vol. 16, no. 4, pp. 809-821, 2009