Red blood cell aggregation and disaggregation in diabetes mellitus

Issue title: Red Cell Aggregation. Proceedings of the Second International Symposium. Paris, France, January 1988

Guest editors: J.F. Stoltz

Article type: Research Article

Authors: Le Dévéhat, C.^{; *} | Vimeux, M. | Bondoux, G. | Bertrand, A.

Affiliations: Unité de Recherches d’Hémorhéologie Clinique, Centre de Diabétologie et des Maladies de la Nutrition, Centre Hospitalier de Nevers, 58320 Pougues les Eaux, France

Correspondence: [*] Correspondence to C. Le Dévéhat.

Note: [] Accepted by: Editor J.F. Stoltz

Abstract: In this study, hematocrit, plasma viscosity, fibrinogen, albumin, red cell aggregation and disaggregation threshold were measured on 20 control subjects and on 438 diabetic patients with and without vascular complications, with good and poor metabolic control. The rheological disturbances were characterized by a significant increase of red cell aggregation tendency at low shear rate, of red cell disaggregation thresholds, and by a significant increase of fibrinogen level and decrease of albumin level. The rheological disturbances observed may confirm the role of rheological phenomena in the genesis of diabetic microangiopathy.

Keywords: Diabetes mellitus, Hemorheology, Red cell aggregation, Red cell disaggregation, Fibrinogen

DOI: 10.3233/CH-1989-9515

Journal: Clinical Hemorheology and Microcirculation, vol. 9, no. 5, pp. 845-854, 1989