A hydroxyethyl starch-hemoglobin polymer as a blood substitute

Article type: Research Article

Authors: Cerny, L.C.^a | Stasiw, D.M.^a | Cerny, ^a | Baldwin, J.E.^b | Gill, B.^b

Affiliations: [a] Masonic Medical Research Laboratory, Utica College of Syracuse University, Utica, NY | [b] Dyson Perrins Laboratory, Oxford University, Oxford, England

Note: [] Accepted by: Editor S. Chien

Abstract: A group of polymers has been synthesized using hemoglobin from out-dated blood and starch. These new materials have been characterized with respect to molecular weight, intrinsic viscosity and hemoglobin content. Preliminary studies on the starch-hemoglobin polymers indicate that these compounds will transport oxygen to the tissues, have satisfactory oncotic properties and provide adequate hemodilution when used in transfusion.

Keywords: Hydroxyethyl starch, hemoglobin, polymer, blood substitute

DOI: 10.3233/CH-1982-2412

Journal: Clinical Hemorheology and Microcirculation, vol. 2, no. 4, pp. 355-365, 1982