Extract of Oxytropis pseudoglandulosa inhibits vascular smooth muscle cell proliferation and migration via suppression of ERK1/2 and Akt signaling pathways¹

Issue title: Special Issue in Honour of the Editor-in-Chief Prof. Dr. Ing. Friedrich Jung on his 70th Birthday

Article type: Research Article

Authors: Lee, Jiyun^a | Lee, Chang Youn^b | Seo, Hyang-Hee^a | Bazarragchaa, Badamtsetseg^c | Batdelger, Gantuya^d | Choi, Sangho^e | Hwang, Ki-Chul^f | Lee, Seahyoung^{f; *} | Lim, Soyeon^{f; *}

Affiliations: [a] Brain Korea 21 PLUS Project for Medical Science, Yonsei University, Seoul, Korea | [b] Department of Integrated Omics for Biomedical Sciences, Yonsei University, Seoul, Korea | [c] Mongolian Museum of Natural History, Ulaanbaatar, Mongolia | [d] Institute of General and Experimental Biology, Mongolian Academy of Sciences (MAS), Ulaanbaatar, Mongolia | [e] International Biological Material Research Center (IBMRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Korea | [f] Institute for Bio-Medical Convergence, College of Medicine, Catholic Kwandong University, Gangneung, Gangwon-do, Korea

Correspondence: [*] Corresponding author: Seahyoung Lee and Soyeon Lim, Institute for Bio-Medical Convergence, College of Medicine, Catholic Kwandong University, Gangneung, 25601 Gangwon-do, Korea. Tel.: +82 32 290 2775 (Seahyoung Lee) and +82 32 290 2777 (Soyeon Lim); E-mails: sam1017@ish.ac.kr (Seahyoung Lee) and slim724@cku.ac.kr (Soyeon Lim).

Note: [1] The manuscript is dedicated to Prof. F. Jung on the occasion of his 70th birthday.

Abstract: Excessive vascular smooth muscle cell (VSMC) proliferation and migration accelerate the development of occlusive vascular disease. Therefore, finding a means to control the aberrant proliferation and migration of VSMCs has own clinical significance. In the present study, we examined the feasibility of using extract from medicinal plant Oxytropis pseudoglandulosa (OG) to control pathologic proliferation and migration of VSMCs, which never have been tested. Our data indicate that the extract of OG significantly suppressed proliferation and migration of VSMCs without cytotoxic effect, suggesting the OG extract may be an alternative agent to effectively control the aberrant VSMC proliferation and migration without any serious adverse effect. These data suggest that the extract of OG may be a potent therapeutic agent for the treatment of occlusive vascular disease and warrant further studies to identify the major acting ingredient and to validate in vivo efficacy.

Keywords: Oxytropis pseudoglandulosa , vascular smooth muscle cell, proliferation, migration

DOI: 10.3233/CH-189126

Journal: Clinical Hemorheology and Microcirculation, vol. 69, no. 1-2, pp. 277-287, 2018