The diagnostic value of contrast-enhanced ultrasound (CEUS) as a new technique for imaging of vascular complications in renal transplants compared to standard imaging modalities

Issue title: Selected papers of the 36th Conference of the German Society for Clinical Microcirculation and Hemorheology, 5–8. June, 2017, Greifswald, Germany

Guest editors: M. Jünger, A. Krüger-Genge and F. Jung

Article type: Research Article

Authors: Mueller-Peltzer, K.^{a; *} | Rübenthaler, J.^a | Fischereder, M.^b | Habicht, A.^b | Reiser, M.^a | Clevert, D.-A.^a

Affiliations: [a] Department of Radiology, Ludwig-Maximilians-University Munich – Grosshadern Campus, Munich, Germany | [b] Department of Internal Medicine IV, Ludwig-Maximilians-University Munich – Grosshadern Campus, Munich, Germany

Correspondence: [*] Corresponding author: Katharina Mueller-Peltzer, M.D., Department of Radiology, Interdisciplinary Ultrasound Center, Ludwig-Maximilians-University Munich – Grosshadern Campus, Marchioninistr. 15, 81377 Munich, Germany. Tel.: +49 89 4400 73627; Fax: +49 89 4400 78832; E-mail: Katharina.MuellerPeltzer@med.uni-muenchen.de.

Abstract: BACKGROUND:Vascular complications in renal transplant patients are a well-known issue in post transplant patient care. If malfunctioning of the renal transplant is suspected to be caused by vascular complications an early diagnosis and therapy is required to maintain the renal transplant. Computed tomography (CT), digital substraction angiography (DSA) and radioisotope renography are the gold standard imaging modalities to diagnose vascular complications. OBJECTIVE:To analyse the sensitivity and specificity of contrast-enhanced ultrasound (CEUS) in comparison to the standard imaging modalities CT, DSA and radioisotope renography in the diagnosis of vascular complications in renal transplant patients. Methods:A total of 33 renal transplant recipients with elevated kidney function parameters with initial diagnostic imaging between 2006 and 2017 were included in the study. The imaging studies and clinical data were analysed retrospectively. The diagnostic accuracy of CEUS was compared to CT, DSA and renal scintigraphy respectively which are classified as gold standard for diagnosis of vascular complications in renal transplant patients. Out of 23 patients 15 patients showed vascular complications in CT, DSA or radioisotope renography and in 15 out of 15 patients CEUS detected the vascular complication. RESULTS:CEUS showed a sensitivity of 100%, a specificity of 66.7%, a positive predictive value (PPV) of 71.4%, and a negative predictive value (NPV) of 100%. CONCLUSIONS:CEUS is a non-nephrotoxic and safe method for the initial imaging of vascular complications in renal transplant recipients. Compared to the gold standard imaging modalities CT, DSA and radioisotope renography CEUS shows a high sensitivity and NPV in detecting vascular complications. In cases with suspected stenosis of the transplant renal artery additional DSA might be needed.

Keywords: Contrast-enhanced ultrasound, CEUS, CT, DSA, renal transplant, vascular complications

DOI: 10.3233/CH-179221

Journal: Clinical Hemorheology and Microcirculation, vol. 67, no. 3-4, pp. 407-413, 2017